• Comparatively cell based assays appear to be the most sensit

  2024-05-15

  

  Comparatively, cell-based assays appear to be the most sensitive method to detect patient autoantibodies directed at neurotransmitter receptors. Leite et al. demonstrated that many α-BTX RIA seronegative myasthenic patients do have autoantibodies against the AChR when a highly sensitive immunofluore

• It has been reported that HT R involves in

  2024-05-15

  

  It has been reported that 5-HT2R involves in type 2 diabetes mellitus and 5-HT-induced IR [22,23]. The present study also demonstrated that it is 5-HT2R rather than other 5-HT receptors, including 5-HT1BR and 5-HT7R, in the liver that mediates HFD-induced abnormality of hepatic lipid metabolism, and

• br Author contributions br Conflict

  2024-05-15

  

  Author contributions Conflict of interest Acknowledgements This work was supported by the National Natural Science Foundation of China (81502276), Major Projects of Science and Technology of Health and Family Planning Commission of Hunan Province (A2017013), the Natural Science Foundation o

• Iohexol br Conclusions br Acknowledgments br Introduction To

  2024-05-15

  

  Conclusions Acknowledgments Introduction To die or not to die – that is the question. Christian de Duve created the word “autophagy” in 1960’s for the first time (Klionsky et al., 2016). The word “autophagy” was derived from the Greek roots “auto” (self) and “phagy” (eating) and referred to

• Previously using a P lacZ reporter gene system it

  2024-05-15

  

  Previously, using a P-lacZ reporter gene system, it has been shown that the β-galactosidase activity was 9-fold higher in the stationary phase urokinase when compared with those of the exponential phase [15]. Furthermore, inositol supplementation did not have a major effect on the expression of β-g

• While it is known that circulating LDL C levels

  2024-05-15

  

  While it is known that circulating LDL-C levels are largely regulated by either controlling the rate of hepatic production of its triglyceride-rich precursor VLDL particle or the rate of LDLR-mediated LDL particle clearance [58], it should be noted that important differences exist between rodents an

• Although many factors influence the effects of medications d

  2024-05-15

  

  Although many factors influence the effects of medications, during recent years it has become evident that genetic factors could explain the differences between individuals in drug response. These differences are due to variants in genes encoding drug targets [8]. The challenge for pharmacogenetics

• To examine whether the interaction between mGlu and

  2024-05-14

  

  To examine whether the interaction between mGlu7 and α1-adrenergic receptors could be confirmed at a behavioural level, we performed the FST in mice. This test has value in predicting the antidepressant-like effect of drugs or environmental manipulations (Krishnan and Nestler, 2008, Krishnan and Nes

• In particular we focused our

  2024-05-14

  

  In particular, we focused our attention on beta2 adrenergic receptors, since their commercial inhibitors are effective in lowering IOP, the primary indication of glaucoma. The hypotensive action of a commercial sequence of beta2 adrenergic receptor siRNA was tested in rabbits. The results confirmed

• br Materials and methods br Results br Discussion More exper

  2024-05-14

  

  Materials and methods Results Discussion More experiments were performed in order to explain the mechanism that is involved in phosphocholine mg death both PC3 and Hep G2 cells using compound 5. Results showed that this compound inhibits cell viability inducing apoptosis in a concentration-

• We have previously reported alterations of the thymus in ACh

  2024-05-14

  

  We have previously reported alterations of the thymus in AChR-MG patients, especially in their germinal center glibenclamide (defined as CD19+CD38+ cells by flow cytometric analysis). First, we found that, in MG thymi, this subset failed to show the normal down-regulation of Bcl-2, suggesting that

• Concerning asthma in a study

  2024-05-14

  

  Concerning asthma, in a study evaluating the effect of tiotropium in severe asthma, the sputum eosinophil count and exhaled nitric oxide were also assessed. However, evaluation of the anti-inflammatory effect of tiotropium was difficult because these markers were low at baseline and thereafter. In a

• Regarding the HT B receptors they act as terminal receptors

  2024-05-14

  

  Regarding the 5-HT1B receptors, they act as terminal receptors and are involved in the presynaptic regulation of the release of 5-HT. But at spinal level these receptors are principally situated post-synaptically (Sari, 2004). The ability of autoreceptors to regulate extracellular levels of 5-HT dur

• pmsf Several tertiary prevention studies are currently under

  2024-05-14

  

  Several tertiary prevention studies are currently underway examining the use of dutasteride for prostate cancer treatment: (1) during expectant management of prostate cancer, (2) after radical prostatectomy in men at high risk for relapse, and (3) in men with metastatic disease. The Reduction by Dut

• If the lack of specificity

  2024-05-14

  

  If the lack of specificity and the high pleiotropy may represent a problem in view of the potential chemotherapeutic features of autophagy-inducing agents, it adrenergic receptors may switch into an advantage in the case of chemopreventive strategies. In fact, as non-pharmacologic interventions suc

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