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Pituitary adenylate cyclase activating polypeptide PACAP is
2023-10-30
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a member of the secretin/growth hormone-releasing hormone (GHRH)/vasoactive intestinal peptide (VIP) family, with potent anti-inflammatory and potent cytoprotective properties [[6], [7], [8], [9], [10], [11], [12], [13]]. PACAP exists as
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Extracellular ATP and downstream purinergic
2023-10-30
Extracellular ATP and downstream purinergic signaling have also been proposed to contribute to dental pulp tissue healing and dentin regeneration. Mechanical and thermal stimulation of external dentin can induce ATP release in dental pulp through pannexins [13]. Cold stimulation was also reported to
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To better understand the pathophysiology of ASDs we would
2023-10-30
To better understand the pathophysiology of ASDs, we would need comprehensive information on a) the functions of ASD-associated proteins in the brain, b) how mutations affect the expression level and function of these proteins, c) how mutations affect their function in neurons, and d) how changed ne
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Previously we described that cadmium
2023-10-30
Previously, we described that cadmium induces a more pronounced, but not selective, cell death on primary cholinergic neurons from basal forebrain (Del Pino et al., 2014). Degeneration of septal cholinergic neurons from basal forebrain, as happens in AD, results in memory deficits (Scheiderer et al.
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ketorolac toradol mg It is important http www apexbt com
2023-10-30
It is important to note that the administration of THA significantly increased the area immunostained by the anti-pVEGFR2 antibody in medial septal cholinergic neurons. The same treatment slightly increased the expression levels of VEGFR2 in cholinergic neurons; however, this change was not confirme
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Even within the context of
2023-10-30
Even within the context of evidence-based interventions for tobacco screening, the science is imperfect. For example, patients who screen positive for current smoking should receive cessation counseling and prescribed known effective nicotine replacement therapy based on the Public Health Services G
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adrenergic antagonist An AXL decoy receptor with
2023-10-30
An AXL decoy receptor with enhanced GAS6-binding properties, MYD1, was engineered as a therapeutic tool to disrupt GAS6/AXL signaling in vivo (Kariolis et al., 2014). MYD1 was shown to block metastasis of human ovarian cancer adrenergic antagonist and a murine breast cancer cell line in grafting as
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br Antioxidant polymers conjugates Natural antioxidants
2023-10-30
Antioxidant-polymers conjugates Natural antioxidants are usually used as a substitute for synthetics but some degradation phenomena could influence their applications. For example, ascorbic L-690,330 as a natural antioxidant undergoes yellowish coloration as a result of oxidation [29]. Sing and K
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br Brain Angiotensin II receptors The information above leav
2023-10-27
Brain Angiotensin II receptors The information above leaves Angiotensin II receptors as the only RAAS components for which localization, regulation of expression and function in the iwp2 has been convincingly demonstrated, with the use of quantitative film and emulsion autoradiography to study r
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br Introduction Heart Failure HF
2023-10-27
Introduction Heart Failure (HF) is a major and growing health challenge in India and the developing countries. It is one of the most important causes of morbidity and mortality in the industrialized world. The incidence and prevalence estimates of HF are unreliable in India because of the lack of
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Does dietary caffeine interfere with antinociception
2023-10-27
(8) Does dietary caffeine interfere with antinociception by other modalities that alter pain (TENS, exercise, joint mobilization, water immersion therapy)? Caffeine and/or A1R antagonists inhibit antinociception by each of these modalities in preclinical studies, such that there is potential for int
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The purpose of this study is to examine the
2023-10-27
The purpose of this FDA-approved Drug Library study is to examine the relationship between ACEs and engagement in treatment among a sample of youth in residential treatment centers (RTCs). It is hypothesized that youth with higher ACE scores will have lower levels of engagement in treatment. In ord
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br Introduction The vacuolar ATPases V ATPases are
2023-10-27
Introduction The vacuolar ATPases (V-ATPases) are ATP-driven proton pumps that play important roles in both normal and disease processes [1], [2], [3], [4], [5]. V-ATPases within cells function in such processes as intracellular membrane traffic, protein processing and degradation, coupled transp
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br Material and methods br Results br Discussion
2023-10-26
Material and methods Results Discussion Asparagine, arginine, leucine, methionine, and glutamine are the essential EGFR Inhibitor for cancer cells and intensively investigated for the development of selective targeted therapeutics. Among them, asparagine depleting bacterial enzyme asparagi
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Given that the FST protocol for mice
2023-10-26
Given that the FST protocol for mice does not engage the exposure to a previous stressful session, posits that Agtr1a levels could be kept higher by basal glutamatergic transmission rather than by stressful stimuli as postulated before. To address this possibility, we used the EMBL-EBI Expression At
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