• The IV chains of mature GBM are built exclusively by

  2019-09-26

  

  The α3/α4/α5(IV)-chains of mature GBM are built exclusively by podocytes (not by endothelial cells) (Abrahamson et al., 2009), placing the podocytes into the focus of GBM-diseases such as Alport syndrome. Alport syndrome (AS) is caused by mutations in the COL4A3, 4 or 5 genes coding for the α3/α4/α5

• Converging evidence suggests that reduced glutamate transmis

  2019-09-26

  

  Converging evidence suggests that reduced glutamate transmission in the LS is linked to increased anxiety-like behaviors (Radulovic et al., 1999, Henry et al., 2006, Bakshi et al., 2002, Liu et al., 2004). Therefore, attenuated CRF1 receptor-mediated excitatory transmission in the LS following ASV-t

• In the context of our ongoing studies to define

  2019-09-26

  

  In the context of our ongoing studies to define the phytochemical and biological properties of oxyprenylated secondary metabolites of plant and fungal origin, we wish to report herein the investigation on the interaction of some natural and semisynthetic O-alkylcoumarins with promising ChE inhibitor

• AON successfully alleviated the myotonic phenotype in DM mod

  2019-09-26

  

  AON successfully alleviated the myotonic phenotype in DM model mice [18], [23]. To screen for an optimal AON sequence, we used 25-mer phosphorothioate 2′ O-methyl RNA molecules that covered the exon 6B or exon 7A. Unexpectedly, AON 7A (+63−8) which covers the boundary of intron 7A and exon 7A enhanc

• Introduction Neuropathic pain occurs in approximately

  2019-09-26

  

  Introduction Neuropathic pain occurs in approximately one-third of patients with diabetes and is refractory to currently available analgesic drugs (Abbott et al., 2011). This painful diabetic neuropathy (PDN) is associated with elevated levels of methylglyoxal (MG; a reactive glucose metabolite) an

• br In some but not

  2019-09-26

  

  In some, but not all, human vessels, a small population of ETB (usually 4μ8C with atherosclerotic lesions did not show any increase. In agreement, in experimental medicine studies in both heart failure patients and volunteer controls, selective ETA antagonism (BQ123) caused the expected potent va

• azidothymidine Because sex steroids and growth hormone

  2019-09-26

  

  Because sex steroids and growth hormone play an important role in the development and maintenance of hepatic CYP450 enzyme expression and ER expression, it is possible that exposure to endocrine active agents during gestation and perinatally could alter expression of these proteins. Therefore, these

• In rodent models the loss of estrogens through ovariectomy h

  2019-09-25

  

  In rodent models, the loss of estrogens through ovariectomy has been shown to promote the development of intracranial aneurysms. Conversely, the administration of an selonsertib receptor beta agonist restores its protective effect, but is abolished with the introduction of a nitric oxide synthase i

• The involvement of FOXO and STAT in DNA PKcs

  2019-09-25

  

  The involvement of FOXO3 and STAT5 in DNA-PKcs and Asiatic acid IV has not been reported before, and the search by the ECR browser (http://ecrbrowser.decode.org) revealed that 1kb of the 5′ promoter of DNA-PKcs possesses 4 STAT (−908bp to −901bp, −676bp to −656bp, −533bp to −526bp and −66bp to −59b

• In Senegal malaria remains a formidable

  2019-09-25

  

  In Senegal, malaria remains a formidable public health issue, causing significant morbidity and mortality in infants and pregnant women (WHO Malaria Report, 2012). In the absence of an effective vaccine, the National Malaria Control Program has followed WHO recommendations for IPTp-SP since 2003. Th

• br Future directions The proposed membrane topology model of

  2019-09-25

  

  Future directions The proposed membrane topology model of DGAT1 has only three TMDs, with the N-terminus oriented toward the cytosol and the C-terminus in the ER lumen. The catalytic activity is exclusively on the luminal side of the ER membrane. The second and third TM domains are only about 10

• Henderson et al reported that allergen

  2019-09-25

  

  Henderson et al. [20] reported that allergen-induced airway remodeling was blocked by the CysLT1 receptor antagonist montelukast. The development of epithelial thickening and mucus accumulation at relatively small Z-VEID-FMK clinical was also suppressed by montelukast. The CysLT2 receptor antagonis

• Similarly to the chemokine CCL the

  2019-09-25

  

  Similarly to the chemokine CCL-5, the level of the chemokine SDF-1 in the groups of individuals with APD did not differ from its level in the control group. However, a slight increase in the level of this chemokine was recorded in the group of women and men with APD and PTSD as compared with the cor

• No orthologs could be found in our B

  2019-09-25

  

  No orthologs could be found in our B. oleracea BAC library for AtCk1/2, which could mean that it is unique to Arabidopsis, or that we failed to detect it in our library. However, the second possibility is unlikely considering that Southern blotting analysis with four restriction enzymes disclosed fr

• Adding more pieces to the puzzle

  2019-09-25

  

  Adding more pieces to the puzzle, using a human-to-animal crossover study, blood taken from healthy volunteers that underwent exercise was used as a dialysate to perfuse a rabbit heart in a Langendorff model of MI [62]. Unprecedentedly, dialysate of plasma from exercised humans reduced infarct size

14989 records 938/1000 page Previous Next First page 上5页 936937938939940 下5页 Last page