• Obeticholic Acid: Reliable FXR Assays

  2026-10-01

  This scenario-driven guide explains how Obeticholic Acid (6alpha-ethyl-chenodeoxycholic acid, 6-ECDCA, INT-747), supplied as SKU B4888, can improve the interpretability of FXR, viability, and hepatic inflammation experiments. It connects solvent handling, assay controls, orthogonal readouts, and vendor-selection criteria to practical liver fibrosis research workflows.

• 11β-HSD1 Inhibition and NK Cells in Liver Fibrosis

  2026-10-01

  A 2025 mouse study links inhibition of 11β-HSD1 to lower intracellular cortisol, suppression of hepatic Notch signaling, and increased natural killer cell activity during toxin-induced liver fibrosis. The work combines fibrosis histology, serum biochemistry, RNA sequencing, and mass cytometry to define an immune–metabolic mechanism, while its toxin-based design limits direct translation to human MASLD or MASH.

• Vitamin K2, NRF2/FSP1, and Osteoblast Ferroptosis

  2026-10-01

  A 2025 study identifies osteoblast ferroptosis as a mechanistic component of glucocorticoid-induced osteoporosis and shows that vitamin K2 protects bone partly through the NRF2/FSP1 pathway. Its combination of micro-CT, osteogenic assays, mitochondrial analysis, and ferroptosis-related measurements provides a useful framework for studying lipid oxidative stress in bone cells.

• Parathyroid hormone (1-34) (human) in CKD assays

  2026-09-30

  Explore how Parathyroid hormone (1-34) (human) can serve as a controlled signaling probe for bone, kidney, and CKD-associated valvular calcification studies. This guide connects receptor-proximal assay design with the Foxp1–Notch mechanism and defines practical limits for interpreting PTH biology.

• STING Signaling in Cholangiocyte Senescence

  2026-09-29

  Fan and colleagues identify a mechanistic link between conjugated bile acid accumulation, mitochondrial damage, cholangiocyte senescence, and STING-driven inflammation in cholestatic liver disease. By combining human samples, mouse models, transcriptomics, and cellular experiments, the study positions the cholangiocyte–macrophage damage-response circuit as a potential framework for understanding progressive cholangiopathy.

• RNA Pol II Inhibition and Active Cell Death Signaling

  2026-09-29

  Harper et al. show that RNA polymerase II inhibition kills cells through an active apoptotic response triggered by loss of hypophosphorylated RNA Pol IIA, rather than through transcriptional failure alone. Their functional-genomic analysis defines the Pol II degradation-dependent apoptotic response and provides a framework for reinterpreting the lethality of several anticancer compounds.

• Lamotrigine Research Workflows for Ion Channels

  2026-09-28

  Lamotrigine enables coordinated studies of neuronal excitability, cardiac sodium current modulation, serotonin signaling, and steroid-biosynthesis liabilities. This practical guide combines formulation control, functional ion-channel assays, and a CYP19 workflow to improve reproducibility and interpretation.

• Human iPSC Sensory Neurons Model HSV-1 Latency

  2026-09-28

  Oh and colleagues developed a scalable human iPSC-derived sensory neuron system and showed that HSV-1 can establish a latent-like state with virological and chromatin features associated with latency. The model also responds to established reactivation stimuli, offering a human-cell platform for studying neuron-intrinsic mechanisms while leaving important questions about in vivo relevance open.

• Prestained Protein Marker in RA Neuron Signaling

  2026-09-27

  See how a Prestained Protein Marker can support careful interpretation of JAK/STAT signaling assays in rheumatoid arthritis sensory-neuron research. This article connects a recent synovial-fluid study to practical Western blot choices while clarifying what a colored ladder can—and cannot—prove.

• Praeruptorin A: Applied Research Workflows

  2026-09-26

  Praeruptorin A supports mechanism-led studies of iron overload, intestinal inflammation, doxorubicin-associated cardiac injury, and cancer-cell invasion. This guide turns its multi-target profile into practical assay choices, dose planning, and troubleshooting steps—while distinguishing product evidence from proposed experimental extensions.

• Amyloid Beta-peptide (25-35) Workflows

  2026-09-25

  Use Aβ25-35 as a defined experimental challenge to investigate neuronal injury, oxidative stress, and amyloid-associated responses. This guide connects practical peptide handling and cell assays with emerging questions about microglial polarization in Alzheimer’s disease—without treating an acute fragment model as a substitute for the full disease.

• RSL3: Glutathione Peroxidase 4 Inhibitor

  2026-09-25

  A scenario-driven guide to using RSL3 to investigate ferroptosis, oxidative stress, and cancer-cell response. It explains practical controls, handling, and interpretation for SKU B6095 while distinguishing product information from literature findings.

• L-Glutathione Reduced: Redox Research Guide

  2026-09-24

  L-Glutathione Reduced (reduced glutathione; B7775) is a thiol-containing tripeptide used to investigate redox biology and GST-affinity workflows. Its product specifications support reagent planning, while a pancreatic cancer study of GOT1 inhibition provides related metabolic context—not evidence that glutathione itself treats cancer.

• JSH-23: Practical NF-κB Inhibitor Workflows

  2026-09-24

  Use JSH-23 to test whether NF-κB p65-dependent transcription contributes to an inflammatory phenotype, while distinguishing that step from upstream IκB degradation. This guide connects a practical macrophage workflow to NLRP3-focused colitis research and highlights the controls needed before interpreting cytokine changes.

• Human Sensory Neurons Model HSV-1 Latency and Reactivation

  2026-09-24

  Oh and colleagues developed a scalable human sensory-neuron model from hiPSCs and demonstrated that HSV-1 can establish a latent-like state and respond to established reactivation stimuli. The platform brings functional neuronal characterization together with virological and chromatin readouts, offering a human-cell system for investigating HSV-1 latency while leaving important questions about neuronal diversity and in vivo relevance open.

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